JIMT-1 Xenografts
Rincon Bio performs JIMT-1 xenograft models to test efficacy of preclinical therapies. Please see below for additional information or to request a quote.
Breast
JIMT-1 is a carcinoma cell line (designated JIMT-1) from a pleural metastasis of a 62-year old patient with breast cancer who was clinically resistant to trastuzumab. Ref
Oncogene
JIMT-1 cells have an amplified HER-2 oncogene. They overexpress HER-2 mRNA and protein, and the levels of HER-1, HER-3, and HER-4 mRNA and protein are similar to the trastuzumab-sensitive cell line SKBR-3. The cell line lacks expression of hormone receptors (estrogen receptors and progesterone receptors) and is phenotypically of epithelial progenitor cell origin. JIMT-1 cells are insensitive to trastuzumab and another HER-2-inhibiting drug, pertuzumab (2C4), in vitro and in xenograft tumors. Ref
in vivo
Forms tumors in nude mice
Used in xenografts to test the efficacy of novel cancer therapeutics
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Rincon Bio Growth Curve
Cell Line: JIMT1
Mouse Strain: NOD.CB17 Prkdc<Scid>NCrHsd from Envigo
Gender: Female
Positive Control: Kadcyla
Concentration: 2.5mg/kg, 5mg/kg
Matrigel: Yes
Dosing: One dose, tail vein
From implant to stratification: 20 days
Cells Implanted per Animal: 5 million
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