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SK-N-AS is a bone marrow metastasis from a child with poorly differentiated embryonal neuroblastoma.


SK-N-AS cells synthesize Insulin-like growth factor II (IFG-II) and IGF-II RNA and possess type I IGF receptors.  Retinoic acid partially inhibits proliferation, and cells fail to differentiate.  The cells exhibit low or no MDR1 expression.

in vivo

Forms tumors in nude mice

Used in allogeneic xenografts

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