SK-N-AS is a bone marrow metastasis from a child with poorly differentiated embryonal neuroblastoma.
SK-N-AS cells synthesize Insulin-like growth factor II (IFG-II) and IGF-II RNA and possess type I IGF receptors. Retinoic acid partially inhibits proliferation, and cells fail to differentiate. The cells exhibit low or no MDR1 expression.
Forms tumors in nude mice
Used in allogeneic xenografts