rincon bio

SK-N-AS is a bone marrow metastasis from a child with poorly differentiated embryonal neuroblastoma.

SK-N-AS cells synthesize Insulin-like growth factor II (IFG-II) and IGF-II RNA and possess type I IGF receptors.  Retinoic acid partially inhibits proliferation, and cells fail to differentiate.  The cells exhibit low or no MDR1 expression.

Forms tumors in nude mice

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Used in allogeneic xenografts

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