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PL-21 was derived from a 24 year old man with refractory acute promyelocytic leukemia after granulocytic sarcoma


PL-21 cells do not carry the t(15;17); based on morphology, surface marker expression of CD14/CD68 and expression of the monocyte-specific esterase, PL-21 cells appear to be rather of monocytic origin; differentiation is inducible by phorpbol ester; cells carry an FLT3 internal tandem duplication. Ref

in vivo

Used in allogeneic xenografts

Tumors grow in nude mice

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