Rincon Bio

CANCER EFFICACY

MODELS

QUOTE REQUEST FORM

xenograft or syngeneic studies

Rincon Bio performs allogeneic and syngeneic xenograft studies.

Xenograft models entail the implantation of human cancer cells into a host animal, typically an immunocompromised mouse or rat. Xenograft tumor models are effective tools for assessing in vivo efficacy of candidate cancer drugs.

With syngeneic models, the tumor cell line is derived from the same species as the host animal. Syngeneic models can thus test the efficacy of immuno-oncology agents as single therapies, or in combination with other anti-cancer drugs. Rincon Bio performs syngeneic studies in mice.

Other options include custom xenograft study designs, fluorescent imaging, MTD studies, pre-clinical drug formulation, tumor collection, organ collection, histology, and pharmacodynamic studies (ELISA, Luminex, PCR, sequencing).

Please see below for available models

Please fill out the form below

We will respond with a quote within one business day

AVAILABLE MODELS

Filter items with Model Type

SyngeneicXenograft

Cell line	Model Type	Organ	Mutations	Weeks from stratification to termination (average)
22Rv1	Xenograft	Prostate	KMT2D, PIK3CA, TP53	5
4T1	Syngeneic	Breast	Unavailable	4
786-0	Xenograft	Renal	PTEN, TERT, TP53, VHL	N/A
A-375	Xenograft	Skin	BRAF, CDKN2A, TERT	4
A20	Syngeneic	Blood	Unavailable	N/A
A431	Xenograft	Skin	TP53, EGFR-PPARGC1A fussion	N/A
A498	Xenograft	Renal	PIK3CB, VHL	5
A549	Xenograft	Lung	KRAS, STK11, TP53	6
A673	Xenograft	Sarcoma	BRAF, TP53, EWS-FLI1 fusion	3
AB22	Syngeneic	Lung	CDKN2A	N/A
AGS	Xenograft	Gastric	CTNNB1, KRAS, PIK3CA, TP53	6
B16-F10	Syngeneic	Skin	Unavailable	2
BxPc-3	Xenograft	Pancreatic	BRAF, KRAS, TP53	7
CHLA-06	Xenograft	Brain	TP53	6
CT26	Syngeneic	Colon	KRAS	2.5
CT26.CL25	Syngeneic	Colon	KRAS	2.5
Caki-1	Xenograft	Renal	RB1	4
Cloudman S91	Syngeneic	Skin	Unavailable	N/A
Colo-205	Xenograft	Colon	APC, BRAF, CTNNB1, TP53	2.5
Colon-26 (MC26)	Syngeneic	Colon	Unavailable	4
D4M3A	Syngeneic	Skin	Unavailable	2
DLD-1	Xenograft	Colon	APC, ACVR2A, B2M, EP300, KRAS, PIK3CA, TGFBR2, TP53	4
DU-145	Xenograft	Prostate	CDKN2A, RB1, STK11, TP53	6
EMT6	Syngeneic	Breast	Unavailable	5
ES-2-luc	Xenograft	Ovarian	BRAF, PALB2, TERT, TP53	3.5
HCC1954	Xenograft	Breast	PIK3CA, TP53, CLTC-VMP1 fusion	7
HCT-116	Xenograft	Colon	ACVR2A, BRCA2, CDKN2A, CTNNB1, EP300, KRAS, PIK3CA, PPM1D, TGFBR2, TP53	5
HT-29	Xenograft	Colon	APC, BRAF, PIK3CA, SMAD4, TP53	N/A
HuCCT1	Xenograft	Bile Duct	KRAS, MSH6, TP53	5
Huh-7	Xenograft	Liver	KDR, POLD3, TERT, TP53	4
JIMT-1	Xenograft	Breast	PIK3CA, TP53	8
JeKo-1	Xenograft	Blood	TP53	5
LASCPC-01	Xenograft	Prostate	Unavailable	3
LNCaP	Xenograft	Prostate	AR, MEN1, PIK3R1, PTEN, TP53	4
Lewis Lung LLC1	Syngeneic	Lung	Unavailable	3
MBT-2	Syngeneic	Bladder	Unavailable	5.5
MC38	Syngeneic	Colon	Unavailable	4
MDA-MB-231	Xenograft	Breast	CDKN2A, CDKN2B, BRAF, KRAS, TERT, TP53	4
MDA-MB-468	Xenograft	Breast	PTEN, RB1, TP53	N/A
MIAPaCa-2	Xenograft	Pancreatic	KRAS, TP53	8
MOLM-13	Xenograft	Blood	FLT3, KMT2A-MLLT3 fusion	14
NCI-H1703	Xenograft	Lung	CDKN2A, TP53	3
NCI-H1975	Xenograft	Lung	EGFR, PIK3CA, TP53	6
NCI-H460	Xenograft	Lung	KRAS, PIK3CA, STK11, TP53	5
NCI-N87	Xenograft	Gastric	ERBB3, TP53	6
OCI-AML-3	Xenograft	Blood	DNMT3A, NRAS, NPM1	2
OCI-Ly1	Xenograft	Blood	Unavailable	N/A
OVCAR8	Xenograft	Ovarian	CTNNB1, ERBB2, KRAS, TP53	8
P388	Syngeneic	Blood	Unavailable	N/A
PANC-1	Xenograft	Pancreatic	KRAS, TP53	3
PC-3	Xenograft	Prostate	TP53	4
SK-BR-3	Xenograft	Breast	TP53	4
SK-N-FI	Xenograft	Brain	NF1, TP53	4
SK-N-MC	Xenograft	Sarcoma	TP53, EWS-FLI1 fusion	3
SK-OV-3	Xenograft	Ovarian	APC, FBXW7, PIK3CA, TP53	10
SKM-1	Xenograft	Blood	ASXL1, BCORL1, EZH2, KRAS, TP53	3
SU-DHL-16	Xenograft	Blood	Unavailable	4
SW480	Xenograft	Colon	APC, KRAS, TP53	4
TT	Xenograft	Thyroid	RET, TBX3	4
U-87MG	Xenograft	Brain	Unavailable	3
U118-MG	Xenograft	Brain	IDH1, PTEN, TP53	6
UM-UC-3	Xenograft	Bladder	KRAS, PARD3B, TERT, TP53	N/A
VcAP	Xenograft	Prostate	MLH1, TP53, TMPRss2-ERG fusion	N/A
WITT (SK-Cha-1)	Xenograft	Bile Duct	Unavailable	N/A
WM164	Xenograft	Skin	BRAF	6
YAPC	Xenograft	Pancreatic	KRAS, TP53	N/A