SNU-16 were derived from a 33 year old Asian female with gastric carcinoma.
myc +; erb B2 +,Blood Type A; Rh +,The cells express the surface glycoproteins carcinoembryonic antigen (CEA) and TAG 72.
SNU-16 cells were positive for VIP receptors but lacked gastrin receptors.
The line was established from cells taken prior to chemotherapy.
No evidence of amplification or rearrangements has been noted in the N-myc, L-myc, myb and EGF receptor genes. The c-myc proto-oncogene was apmplified, but expressed c-erb-B-2 RNA that were comparable to other cell lines. There was no expression of the following genes: N-myc, L-myc, c-cis, IGF-2, or gastrin releasing peptide.
The cells express the surface glycoproteins carcinoembryonic antigen (CEA) and TAG-72. The cells are L-dopa decarboxylase (DDC) positive. Ref
Used in allogeneic xenografts
Tumors develop in nude mice