Xenograft & Syngeneic Tumor Models

Cell line	Organ	Model Type	Mutations	Weeks from stratification to termination (average)
22Rv1	Prostate	Xenograft	KMT2D, PIK3CA, TP53	5
4T1	Breast	Syngeneic	Unavailable	4
786-0	Renal	Xenograft	PTEN, TERT, TP53, VHL	N/A
A-375	Skin	Xenograft	BRAF, CDKN2A, TERT	4
A20	Blood	Syngeneic	Unavailable	N/A
A431	Skin	Xenograft	TP53, EGFR-PPARGC1A fussion	N/A
A498	Renal	Xenograft	PIK3CB, VHL	5
A549	Lung	Xenograft	KRAS, STK11, TP53	6
A673	Sarcoma	Xenograft	BRAF, TP53, EWS-FLI1 fusion	3
AB22	Lung	Syngeneic	CDKN2A	N/A
AGS	Gastric	Xenograft	CTNNB1, KRAS, PIK3CA, TP53	6
B16-F10	Skin	Syngeneic	Unavailable	2
BxPc-3	Pancreatic	Xenograft	BRAF, KRAS, TP53	7
CHLA-06	Brain	Xenograft	TP53	6
CT26	Colon	Syngeneic	KRAS	2.5
CT26.CL25	Colon	Syngeneic	KRAS	2.5
Caki-1	Renal	Xenograft	RB1	4
Cloudman S91	Skin	Syngeneic	Unavailable	N/A
Colo-205	Colon	Xenograft	APC, BRAF, CTNNB1, TP53	2.5
Colon-26 (MC26)	Colon	Syngeneic	Unavailable	4
D4M3A	Skin	Syngeneic	Unavailable	2
DLD-1	Colon	Xenograft	APC, ACVR2A, B2M, EP300, KRAS, PIK3CA, TGFBR2, TP53	4
DU-145	Prostate	Xenograft	CDKN2A, RB1, STK11, TP53	6
EMT6	Breast	Syngeneic	Unavailable	5
ES-2-luc	Ovarian	Xenograft	BRAF, PALB2, TERT, TP53	3.5
HCC1954	Breast	Xenograft	PIK3CA, TP53, CLTC-VMP1 fusion	7
HCT-116	Colon	Xenograft	ACVR2A, BRCA2, CDKN2A, CTNNB1, EP300, KRAS, PIK3CA, PPM1D, TGFBR2, TP53	5
HT-29	Colon	Xenograft	APC, BRAF, PIK3CA, SMAD4, TP53	N/A
HuCCT1	Bile Duct	Xenograft	KRAS, MSH6, TP53	5
Huh-7	Liver	Xenograft	KDR, POLD3, TERT, TP53	4
JIMT-1	Breast	Xenograft	PIK3CA, TP53	8
JeKo-1	Blood	Xenograft	TP53	5
LASCPC-01	Prostate	Xenograft	Unavailable	3
LNCaP	Prostate	Xenograft	AR, MEN1, PIK3R1, PTEN, TP53	4
Lewis Lung LLC1	Lung	Syngeneic	Unavailable	3
MBT-2	Bladder	Syngeneic	Unavailable	5.5
MC38	Colon	Syngeneic	Unavailable	4
MDA-MB-231	Breast	Xenograft	CDKN2A, CDKN2B, BRAF, KRAS, TERT, TP53	4
MDA-MB-468	Breast	Xenograft	PTEN, RB1, TP53	N/A
MIAPaCa-2	Pancreatic	Xenograft	KRAS, TP53	8
MOLM-13	Blood	Xenograft	FLT3, KMT2A-MLLT3 fusion	14
NCI-H1703	Lung	Xenograft	CDKN2A, TP53	3
NCI-H1975	Lung	Xenograft	EGFR, PIK3CA, TP53	6
NCI-H460	Lung	Xenograft	KRAS, PIK3CA, STK11, TP53	5
NCI-N87	Gastric	Xenograft	ERBB3, TP53	6
OCI-AML-3	Blood	Xenograft	DNMT3A, NRAS, NPM1	2
OCI-Ly1	Blood	Xenograft	Unavailable	N/A
OVCAR8	Ovarian	Xenograft	CTNNB1, ERBB2, KRAS, TP53	8
P388	Blood	Syngeneic	Unavailable	N/A
PANC-1	Pancreatic	Xenograft	KRAS, TP53	3
PC-3	Prostate	Xenograft	TP53	4
SK-BR-3	Breast	Xenograft	TP53	4
SK-N-FI	Brain	Xenograft	NF1, TP53	4
SK-N-MC	Sarcoma	Xenograft	TP53, EWS-FLI1 fusion	3
SK-OV-3	Ovarian	Xenograft	APC, FBXW7, PIK3CA, TP53	10
SKM-1	Blood	Xenograft	ASXL1, BCORL1, EZH2, KRAS, TP53	3
SU-DHL-16	Blood	Xenograft	Unavailable	4
SW480	Colon	Xenograft	APC, KRAS, TP53	4
TT	Thyroid	Xenograft	RET, TBX3	4
U-87MG	Brain	Xenograft	Unavailable	3
U118-MG	Brain	Xenograft	IDH1, PTEN, TP53	6
UM-UC-3	Bladder	Xenograft	KRAS, PARD3B, TERT, TP53	N/A
VcAP	Prostate	Xenograft	MLH1, TP53, TMPRss2-ERG fusion	N/A
WITT (SK-Cha-1)	Bile Duct	Xenograft	Unavailable	N/A
WM164	Skin	Xenograft	BRAF	6
YAPC	Pancreatic	Xenograft	KRAS, TP53	N/A

Fluorescent and luminescent imaging
Pharmacokinetic studies
MTD and tolerability studies
Tumor and organ collection
Histology and animal pathology
Pharmacodynamic assays, including ELISA, Mesoscale/Luminex, PCR, flow cytometry, and sequencing
Complementary cell-based in vitro assays supporting in vivo studies

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