NCI-N87  Xenografts

 

 

Rincon Bio performs NCI-N87 xenograft models to test efficacy of preclinical therapies.  Please see below for additional information or to request a quote. 

Gastric

NCI-N87 were derived from a patient with gastric cancer

Oncogene

Cells express the surface glycoproteins carcinoembryonic antigen (CEA) and TAG 72, and are L-dopa decarboxylase (DDC) negative. They were minimally positive for vasoactive intestinal peptide (VIP) receptors and lacked gastrin receptors. They were found to express receptors for muscarinic cholinergic agents. No evidence of amplification or rearrangements was noted with the N-myc, L-myc, myb and EGF receptor genes. The cell line expressed levels of c-myc and c-erb-B 2 RNA that were comparable to other cell lines.There was no expression of the following genes: N-myc, L-myc, c-cis, IGF-2, or gastrin releasing peptide. NCI-N87 cells have a reported plating efficiency of 4.3%. Ref

in vivo

Used in xenografts to test the efficacy of novel cancer therapeutics.  Tumors develop after being injected into the flank of immunocompromised mice. 

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Receive a quote within one business day for an NCI-N87 xenograft

Rincon Bio Growth Curves

NCI-N87 Trastuzumab Positive Control

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Cell Line: NCI-N87

Mouse Strain: NOD.CB17 Prkd<Scid>/NCrHsd from Envigo

Gender: Female

Positive Control: Trastuzumab

Concentration: 20mg/kg

Matrigel: Yes

Cells Implanted per Animal: 5 million

From implant to stratification: 22 days

Stratification Size: 100mm^3

Dosing: Tail Vein, 4 times

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Vehicle and Trastuzumab 20mg/kg dosed 4 times

NCI-N87 Kadcyla Positive Control

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NCI-N87

Positive Control: Kadcyla

Concentration: 5mg/kg

Dosing: 4 doses, tail vein

From implant to stratification: 13 days

Cells Implanted: 5 million cells

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RINCON BIO?

DOMESTIC QUALITY at COMPETITIVE PRICES

 

When you work with Rincon Bio, rest assured that all cancer efficacy studies will be performed in the USA, at competitive prices

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Most efficacy studies can be initiated within two business days.

PERSONAL TOUCH

 

We love our clients!  We are flexible and easy to work with.  And we take a personal interest in our clients' studies.